Using the original Friedwald calculation CLDL=CPLASMA-CHDL-TG/5 (all mg/dl)
and the correct conversion factors for mg/dl to mmol/l (x0.02586 for
cholesterol; x0.01129 for triglyceride)the correct factor is 0.458105,
reciprocal of 2.182908.
Ref. Friedwald WT et al Clin Chem(1972) 18: 499-502
-----Original Message-----
From: Jonathan Kay
[mailto:[log in to unmask]]
Sent: 25 November 1999 01:49
To: [log in to unmask]
Subject: Lipid calculations
According to the British Cardiac Society recommendations (Heart, Dec
1998, Vol 80, Supp 2, pS25) the Friedewald formula is, using mmol/L:
LDL cholesterol = total cholesterol - HDL cholesterol - (0.45 x
triglyceride).
Except some colleagues tell me the factor should be 0.46, not 0.45.
Can someone post the "correct" value or the reason for the discrepancy
(possibly rounding of a factor that was originally created using
different units, possbly a typo) so that I don't have to go and find the
literature myself?
Thanks in advance
Dr Jonathan Kay
University of Oxford
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