We use Bayer's Clinitek-100 for specific gravity estimation. The
measurement is based on pKa change (and thus color change) of
polyelectrolytes on the strip, by ionic substances in the urine. Does
anyone know or have reference about differential reactions of different
urine components with these polyelectrolytes? There is not much information
in the package insert except mention about glucose that results are not
effected by the presence of glucose. Question is, does urea and creatinine
contribute to color development, if so how much as compared to strongly
ionic components such as sodium? How good (or bad) is the correlation
between specific gravity measurement by this method as compared to others,
and compared to refractrometry and osmolality? Thanks for your
comments/suggestions.
Uttam Garg, PhD, DABCC
Associate Professor
Director of Clinical Chem & Toxicology and
Co-Director of Biochem Genetics Labs
Children's Mercy Hospital
Kansas City, MO 64108
Phone: 816-234-3803
Fax: 816-234-3794
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