> From: Roger Ekins <[log in to unmask]>
> qustion of urinary v blood aldosterone measurement is an ancient one. The
> urinary value is more integrated but blood value more physiologically
> meaningful at a particular time. There are two urinary metabolites,
> tetrahydroaldosterone slowly excreted; usually in 12 hours) and the 18
> glucuronide (more rapidly excreted; usually in 6 hours with normal renal
> function). Measurement of plasma aldosterone is not easy even with kits.
> Would advise additional measurement of 18 glucoronide but beware liver
> disease and pregnancy when there can be preferential excretion of a
> metabolite.
> __________________________________________________________________
Do most procedures for urinary aldosterone include an acid hydrolysis step?
Would the acid hydrolysis step as used with the DPC Coat-a-Tube assay only
have a effect on the glucuronide conjugate and not on the
tetrahydroaldosterone?
Is total urinary aldosterone the best measure of overproduction of
aldosterone?
Michael Freemantle
Sullivan Nicolaides Pathology
PO Box 344
Indooroopilly Q4068
Brisbane
Australia 4068
ph +61 (0)7 33778638
fax +61 (0)7 38705989
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