Apologies, I let the last paragraph of my previous e-mail get away
prematurely complete complet with typos. It should read as follows;
"On another note, I recall giving a talk on this subject at one centre and
was accused of being agressive when I suggested to a speaker that his
observation that their group didn't miss any cases of phaeochromocytoma,
using only HMMA as a screening test, was fallacious. It is genarally
accepted that this approach to biochemical diagnosis of phaeo will result in
a high false negative rate. While other analytes have beter nosological
characteristics, it has to be accepted that the biological systems that we
investigate present us with a continuum
ranging from normality to abnormality. It would seem reasonable to assume
the more dynamic and responsive the system that is being investigated, the
less
categorical we can be in our interpretations and comments. The sympathetic
nervous
system would appear to present us with one such dynamic system (ask Rover)."
0.95 interfractile interval for an heterogeneous hospital/GP population
using ASTED with reductive mode ECD
Noradrenaline 75-561 nmol/24h collection 9.0-45.2 nmol/mmol
creatinine
Adrenaline 7-82 nmol/24h collection 0.9-8.8
nmol/mmol creatinine
Dopamine 366-2897 nmol/24h collection 70-275 nmol/mmol
creatinine
Dr WA Bartlett
Consultant Clinical Scientist
Clinical Biochemistry
Birmingham Heartlands Hospital
Birmingham B9 5SS
Tel. No. 0121 766 6611 Ext 5461.
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