Recently, we modified our osmotic fragility test according to
H.C.Godal et al. Scand J Haematol 1980;25:107-12,
which requires only four tubes with NaCl solutions instead of twelve,
thereby limiting the amount of labour.
Our concern is that by having points which lie mainly in the
straight part of the curve, we will miss deviating forms
(e.g. flatter curve than usual). Is there anyone who can tell us the
clinical significance of such flattened curves, the frequency and
associated diseases? Thanks for your comment.
Raymond Wulkan
Zuiderziekenhuis
Rotterdam
The Netherlands
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