Herewith forwarded some comments from our Consultant Haematologist, Dr. John
Burman (e mail, [log in to unmask]
-----Original Message-----
From: Burman John
Sent: 01 September 1999 13:27
To: Royle Chris
Subject: RE: Monitoring Of Iron Therapy
Chris,
Thank you,
To me iron deficiency is best judged by serum/plasma ferritin and iron
overload by % saturation TIBC + serum/plasma ferritin, both types of
measurement are required for overload. I don't know if transferrin
substitutes for TIBC and we would need to check out with an iron overload
expert. Here (RBH) the clinical relevance is that iron overload can have a
cardiac presentation. Iron overload is probably underdiagnosed. There is now
a gene test for deeper confirmation of cause in suspected inherited
haemochromatosis.
John
-----Original Message-----
From: Royle Chris
Sent: 01 September 1999 08:18
To: Burman John
Subject: FW: Monitoring Of Iron Therapy
?? Of interest
Chris
-----Original Message-----
From: Maurice Green [mailto:[log in to unmask]]
Sent: 31 August 1999 19:42
To: Craig Webster
Cc: ACB List
Subject: Re: Monitoring Of Iron Therapy
We are currently replacing our use of TIBC with Transferrin and will
report an Fe/TRFN ratio to replace % saturation. We are still debating
whether to back calculate the TIBC and the % saturation as well.
There was a good review by Beilby in Australia a few years back on this
problem:
Beilby J, et al.
Transferrin index: an alternative method for calculating the iron
saturation of transferrin.
Clin Chem. 1992 Oct;38(10):2078-81.
PMID: 1394993; UI: 93008960.
and a fair number of other papers I found in my Medline search
--
maurice green, phd, facb
clinical chemist
stanford hospital
palo alto, ca 94305-5627
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