In message <[log in to unmask]>, ghlester
<[log in to unmask]> writes
>We have been working up Abbott AxSYM Troponin I assay for introduction into
>routine service. Presently we do Vitros total CK with AxSYM CK-MB mass in
>selected cases by special request. We have been doing TnI on these CK-MBs
>in parallel. Findings reinforce the paper in Feb 99 Clinical Chemistry but
>we came across this case which has puzzeled us. Does anyone have any
>experience to throw light on the situation?
>
>A 93 year old lady admitted via A&E (ER for colleagues in US) with history
>of "fall, collapsed, low temperatue ?cause".
>
>Admission: CK 1372 iu/L (Ref Range < 135)
> CK-MB 131 ug/L ( < 7.0 )
> TnI 0.2 ug/L
>
>9 hours later: CK 794
> CK-MB 68.4
> TnI 0.2
> Trop T 0.02 ug/L ( < 0.10 )
>Non-specific ECG changes were noted.
>
>
>35 hours later: CK 428
> CK-MB 22.9
> TnI 0.1
>
>Do the AxSYM CK-MB or TnI assay suffer HMMA effects? Results of CK
>isoenzymes by electrophoresis are awaited.
>
>Thanks
>
>Geoff Lester
>Chemical Pathology Department
>Frenchay Hospital
>BRISTOL UK.
>[log in to unmask]
A HAMSA effect is documented for CK-MB. The cTnI results are consistent with the
cTnT value.
Tjhis is a non cardiac CK/CK-MB elevation
--
Paul Collinson
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