Gina,
I'm assuming you are referring to the "Gastrin Stimulation Test (after
Secretin)", which uses a provocative dose of secretin and then measures
serum gastrin levels in patients with suspected gastrinomas, i.e.
Zollinger-Ellison syndrome. The protocol is given in Tietz's Clinical
Guide to Laboratory Tests, 3rd edition, page 262 as follows: Draw a blood
sample for a fasting gastrin level. Then administer secretin dose (2-3 U/kg
body weight) by injection over 30 seconds. Then draw blood samples for
gastrin levels at 5-min intervals for the next 30 min. A "normal" gastrin
response is either no response or slight suppression. In patients with
gastrinomas, gastrin levels increase paradoxically by 100-200 pg/mL 5 min
after secretin injection.
Secretin is manufactured by Ferring AB, Malmo, Sweden. In the U.S., it is
available from Ferring Pharmaceuticals, Inc. Tarrytown, NY. Tel
1-888-337-7464. According to one of our pharmacists, it must be kept frozen
and it is currently in short supply (at least on this side of the pond).
Hope this helps.
Sal Sena
Salvador F. Sena, Ph.D., DABCC
Associate Director, Clinical Chemistry
Dept. of Pathology and Laboratory Medicine
Danbury Hospital
24 Hospital Avenue
Danbury, CT 06810
Phone: (203) 797-7705
Fax: (203) 731-8061
e-mail: [log in to unmask]
* * * * * The opinions expressed herein are strictly my own and not those of
my employer, spouse, friends, enemies, stockbroker, astrologer, personal
fitness trainer, etc. * * * * *
----------
From: GINA FREDERICK
To: [log in to unmask]
Subject: secretin stimulation test
Date: Friday, March 19, 1999 9:11AM
Does anyone know of a protocol for a Secretin Stimulation Test, for the
assessment of gastric output in MEN? Anyone know where to get Secretin from?
Any information most welcome.
G Frederick.
Derby City General Hospital.
____________________________________________________________________
More than just email--Get your FREE Netscape WebMail account today at
http://home.netscape.com/netcenter/mail
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
|