In message <[log in to unmask]>, Dr. M. Steiner
<[log in to unmask]> writes
>Dear Colleagues,
>
>We have recently met analytical difficulties in a patient who underwent
>splenectomy (mesenteric vein thrombosis, chronic pancreatitis).
>Post-splenectomy platelet counts increased dramatically peaking at
>2,150,000/µl. Potassium in serum (our source material for routine
>clinical chemistry) was repeatedly increased whereas the corresponding
>plasma values were normal (for example 6,1 versus 4,4 mmol/l).
>According to the literature similar problems might be suspected for ASAT
>and LDH. However, we did not see differences for these analytes between
>serum and plasma samples.
>Could you share your experience in similar patients?
>Are other analytes critically affected?
>
>Thank you very much for your input.
>
>Sincerely,
>
>
>Dr. med. Michael Steiner
>University of Rostock
>Institute of Clinical Chemistry and Pathobiochemistry
>Ernst-Heydemann-Str. 6
>D-18057 Rostock
>GERMANY
>
>
>
I have seen similar results with both platelts and white cells when the counts
were very high. Only K affected however.
--
Paul Collinson
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