Dear colleagues,
I recently came across the statement that adverse effects of heparin
include elevation of serum transaminase(s). As I have no first-hand
experience (I simply never looked into this phenomenon), I would
appreciate any comments on the follwong questions:
1. Is this a common finding or is the evidence rather from case reports?
2. Do ALAT and/or ASAT activites rise?
3. Are there any ideas on an underlying mechanism?
4. What is the natural course of the elevated enzyme activities after
cessation of heparin therapy?
5. Do unfractionated and LMW heparins have the same potential to cause
increased transmaninase(s) activities? Is the effect dose-dependent?
Thank you for your input.
Dr. med. Michael Steiner
University of Rostock
Institute of Clinical Chemistry & Pathobiochemistry
Ernst-Heydemann-Str. 6
18057 Rostock
Germany
fax: +49/381/494-7672
email: [log in to unmask]
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