In message <[log in to unmask]>, Zul Verjee
<[log in to unmask]> writes
>We Studied the correlation between plasma and salivary anticonvulsants
>levels including valproate in children some years ago. REF. Therapeutic
>Drug Monitoring, vol. 19 No.6, 1997, 637-642. Valproate levels did not
>correlate. It is a weak acid and changes in pH gradient between plasma and
>saliva may play a role in the interindividual variability of its
>saliva/plasma concentration ratios. Saliva valproate level therefore is not
>useful for TDM.
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>At 11:11 AM 10/1/98 +0100, JP Begley wrote:
>> I've been asked whether it's possible to measure Sodium Valproate in
>>saliva from a young lady with muscular dystrophy and epilepsy who is
>>impossible to bleed. I have no experience of this approach and would have
>>concerns re sample quality and interpretation. Can anyone offer any
>>advice? Joe Begley Clinical Biochemistry Poole Hospital
>
But of course the BNF states that serum valproate is not useful for
routine monitoring of valproate therapy, so why are you measuring it at
all?
--
Michael Colley
Dr. C. M. Colley
Dept. Chemical Pathology,
Princess Margaret Hospital
Swindon SN1 4 JU
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