How fast is it reasonable to expect CK to fall after an acute event?
We recently had a case of a 79 year old lady admitted to Accident &
Emergency with a diagnosis of collapse, CVA. Admission total CK was 15000
iu/l(NR<135). Renal function OK (Urea 5.2mmol/L, Creat 76umol/L) and LFTs
only marginally abnormal (Bili 31 umol/L, ALT 68 (NR<53)others normal).
Subsequntly same sample gave TSH 7.3, Free T4 <2 pmol/L!
24hr later CK had fallen to only 1000 iu/L.
Presumably we are seeing a "wash-out" effect but I was quite surprised at
the speed of fall in CK. Am I wrong to be surprised? How is CK cleared?
Geoff Lester
Chemical Pathology
Frenchay Hospital, Bristol.
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