Dear all,
Thank you for your replies. Here is a summary of the information I received.
Thanks,
Elodie
-Lab 1:
If the initial screen was negative and the prolactin remained at a similar concentration I wouldn’t re-peg.
- Lab 2:
We follow the guidelines which I believe state test for Macroprolactin on every sample <700, and re-test every 12 months.
- Lab 3:
We test annually.
- Lab 4:
Every 5 years, unless there is an unexpected increase in prolactin, previously positive for macro or a change in methodology.
- Lab 5:
For most patients we screen all first time prolactin results over 700 mIU/L with the PEG precipitation method and report the monomeric prolactin with an appropriate reference range. This test has a repeat request time of 700 days so will not get repeated more frequently than that unless the LIMS rule is over-ridden by a clinical scientist or monomeric prolactin is deliberately requested by a clinician.
For the mental health trust patients: The pharmacists looking after these patients have guidelines to try to reduce the impact on prolactin as much as possible so we get a significant proportion of our prolactin requests from them and they need the monomeric prolactin each time on patients with significant macroprolactin.
- Lab 6:
We will only do a PEG precipitation if the clinician specifically asks for Macroprolactin and we no longer report the PEG recovery – we report the Total PRL and monomeric PRL.
- Lab 7:
We repeat after 1 year currently but considering extending that to 4 years.
- Lab 8:
If we have a positive patient they get a macroprolactin check done every time. We don't have any rules over the negative patients. We tend not to repeat the macrocheck within a few years unless there has been a significant increase in the result or a long time interval between analysis. If a patient is being tracked/monitored at a reasonable frequency and you can see a stable result/result declining on treatment we wouldn't check it again.
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