Need to know how many days post onset of symptoms the blood was taken, especially with antibody tests. Accessing that information for already tested samples may be difficult but easier going forward.
Regards
Tony Cambridge
Lead Biomedical Scientist and POCT Manager
T: 01752 430050
E: [log in to unmask]
________________________________________
From: Clinical biochemistry discussion list [[log in to unmask]] on behalf of Jeffrey Slater [[log in to unmask]]
Sent: 28 March 2020 14:21
To: [log in to unmask]
Subject: Re: Corona infection tests
Dear everyone,
Craig has just made an important point.
Saving of blood samples taken from known Corona virus positive patients will be an extremely useful tool for assessing whether test kits are working. If laboratories have the resources to do this and can be done safely then I would suggest allocating freezer space for separated samples so they are available as positive controls. As test kits become widely available the absence of commercial positive controls may prove problematical.
For negative controls I know that laboratories tend not to retain Down’s screening samples these days but those taken even three months ago in European laboratories will almost certainly be Corona virus negative.
Forgive me if you’ve already thought of this but its not been mentioned on the mailbase as yet
Best wishes to you all
Jeff Slater Consultant Clinical Scientist (Retd)
From: Clinical biochemistry discussion list <[log in to unmask]> On Behalf Of Craig Webster
Sent: 28 March 2020 11:20
To: [log in to unmask]
Subject: Re: Corona infection tests
Thanks Anders,
You certaintly right about the varying importance, reliability and performance data!
I have had continuing discussions with new entrance into clinical diagnostics that its not as simple as just just the test and hey presto! difficult line to tread, still wanting to maintain some semblance of standards while at the same time not appearing to blocking enthusiam.
It would nice if the University's collaborated more effectively, now getting daily requests to save samples for this, that and the other....
bw
Craig
Craig Webster
Consultant Clinical Scientist
Acting Pathology Director
Clinical Service Lead - Biochemistry and Immunology
Internal:
15959
Mobile:
+44 7958 577328
Email:
[log in to unmask]
Web:
http://www.uhb.nhs.uk
Office 23 CLS Level -1 UHB
Pathology - University Hospitals Birmingham NHS Foundation Trust
Birmingham, B15 2GW
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From: Clinical biochemistry discussion list <[log in to unmask]> on behalf of Anders Kallner <[log in to unmask]>
Sent: 28 March 2020 06:54:50
To: [log in to unmask]
Subject: Corona infection tests
Dear Jonathans and Craig,
We tried a survey of the market for corona infection marker and kits. We went out broad and asked for availability, characteristics, distributors and formal approval. We ased separately for serological, PCR and POCT tests and separately for control materials and procedures.
Briefly there are more PCR kits on the market than serological We found only two serological which have at least CE or FDA approval (YHLO [China] and EUROIMMUN Medizinische Labordiagnostika AG (Lübeck). PCR kits was available from NaGen dign Co (China), Elitech, Randox/Bosch and Siemens. Control material from Thermos Fisher only.
Only YHLO reported clinical specifications.
There are a number of laboratories which claim that they are close to developing kits, serology kits, POCT kits, PCR kits. We do not k now how close they are but it indicates that there are a number of specialist available, hopefully working towards a common goal. Since there is a lot of potential money at stake (oh yes, lives as well) competition and “fake news” are to be expected.
The survey was a first attempt to learn about the market. However, the outcome was partly disappointing since some or the major players announced that although they had several kits available or in the pipeline, they were not going to answer because of marketing – and competition concerns.
On the other hand one should accept that a survey of this kind has a “best before date” and that the situation changes rapidly and is different in different countries, continents and isles.
There is a lot of information out there naturally of varying importance and reliabilityt.
We have desperately been looking for specifications and found the attached from China. It is a small study – take it for what it is!
There is also a pre-peer-review document from BMJ (attached).
It seems that people, including colleagues and politicians are not quite aware of the nature of the measurement principles and the disease. The value of the test specifications will vary and depend on for instance patient age, when in the course of disease, prevalence in the tested cohort etc etc.
Epidemiology is one thing, diagnosing and treating individuals another and they do not always agree.
Enjoy your weekend!
Anders
Anders Kallner, MD, PhD
Assoc Prof (R)
Karolinska University Hospital
SE 176 71 Stockholm, SWEDEN
Phone: +46 8 51774943
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