Dear all,

    I’m looking for an enthusiastic PhD student to join my group at IGBMC, Strasbourg, France. We are studying the structure and function of the dynein motor protein through an integrated structural biology approach combining x-ray crystallography and high-resolution cryoEM. The dynein motor is a complex and fascinating molecular machine involved in essential cellular processes like mitosis, organelle positioning and the beating of cilia (https://www.ncbi.nlm.nih.gov/pubmed/24064538).  We also have started to work on the dynein motor related ribosome maturation factor Rea1 (https://www.ncbi.nlm.nih.gov/pubmed/30460895).  
     
    Applicants should possess a Master’s or Bachelor’s degree in the life sciences, or a related discipline. The applicant should have experience in molecular biology as well as protein expression and purification. Experience in protein expression in yeast and/or insect cells would be considered an advantage. Training in x-ray crystallography and cryoEM will be provided. English language skills, the ability to work in a team, initiative, flexibility as well as good organizational and learning skills are required.
     
    The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical research institutions in Europe and provides regular synchrotron access as well as cutting-edge cryo-EM facilities like a Titan Krios electron microscope equipped with a Cs corrector, a GIF energy filter, a phase plate and a Gatan summit K2 direct electron detector. An ion beam scanning electron microscope (cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellular tomography studies are also available.
     
    Applicants should send a CV, a one-page summary of their research experience and contact details for two referees till 15th January 2019 to [log in to unmask] The starting date is spring 2019.
     
     
    Selected publications:
Sosnowski P, Urnavicius L, Boland A, Fagiewicz R, Busselez, Papai G & Schmidt H (2018) “The CryoEM structure of the Saccharomyces cerevisiae ribosome maturation factor Rea1.” Elife. 2018 Nov 26;7. pii: e39163. doi: 10.7554/eLife.39163.
     
    Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing coordinates microtubule binding and linker movement.” Bioessays 37: 532-543.
     
    Schmidt H, Zalyte R, Urnavicius L & Carter AP (2015) “Structure of human cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438.
     
    Schmidt H, Gleave ES & Carter AP (2012) “Insights into dynein motor domain function from a 3.3-Å crystal structure” Nat Struct Mol Biol. 19:492-7.

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