Dear Mailbase,
At Birmingham Children's Hospital, we have been verifying the Roche FT3 assay. Currently we send FT3 requests over to the Women's Hospital site where they are run on the Beckman Access II but we are now going to be moving the method over to the Children's Hospital site.
Since the Beckman assay was evaluated around 2010, we have been using the manufacturer quoted reference ranges. However we are assessing this again now and whether there is a need for paediatric age-specific reference ranges or trimester-specific ranges in pregnancy. There appears to be limited data in the literature regarding this with the Roche assay - the data from the Beckman evaluation just states that a "Review of literature does not suggest that the reference interval is different in either neonates or children." with one reference quoted (Kapelari et al. BMC Endocr Disord. 2008 Nov 27;8:15. doi: 10.1186/1472-6823-8-15).
Do any labs use either of these on the Roche, and if so what was the source of your reference ranges? Did you derive them in house (a concern about doing this is cost and sample numbers available) or did you have another source, or have you found that there is no difference and the manufacturer's reference ranges are fine to use?
Kind regards,
Rosie Forster
Clinical Scientist
Birmingham Women's and Children's NHS Foundation Trust
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