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MEDICAL: DISEASES: ZIKA VIRUS :
TREATMENT:
Zika Treatable with Existing Drugs, Says Breakthrough Study
Written by Catharine Paddock PhD
Published: Tuesday 30 August 2016
Medical News Today (MNT)
http://www.medicalnewstoday.com/articles/312596.php
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"We focused on compounds that have the shortest path to clinical use. This
is a first step toward a therapeutic that can stop transmission of this
disease."
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One of the compounds he and his colleagues discovered is the basis for a
drug called Niclosamide that is approved by the Food and Drug
Administration (FDA). The drug is commonly used to treat tapeworm and
animal studies show it is safe for use in pregnancy.
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In theory, doctors could prescribe the drug today, but it needs to undergo
tests to repurpose it as a treatment for Zika virus infection.
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Earlier this year, members of the team had found a link between Zika and
microcephaly - a severe birth defect where babies are born with a much
smaller head and brain. This led to the search for drug compounds that
might prevent the viral damage.
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Repurposing screen sifted through 6,000 existing drugs
For their new work, the team developed a drug repurposing screen, a
relatively new method that researchers are using to speed up drug
development.
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snip
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The two classes of compounds they identified are capable of protecting
brain cells from cell death induced by Zika virus activity.
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One class of compounds is antiviral in nature and stops the virus
multiplying.
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The other class of compounds is neuroprotective in nature and stops the
virus carrying out cell-damaging "caspase-3 activity" in human cortical
neural progenitors - precursors to brain cells in fetal development.
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The complete article may be read at the URL above.
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Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[log in to unmask]
http://workface.com/e/daviddillard
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