Good afternoon,
I would appreciate it if anyone has come across and overcome the following problem. In Belfast we run a digoxin assay on a Roche Cobas system. Conventional practice has been to analyse samples taken 6-8 hours post-dosing, however the Roche literature stipulates testing 12 hours post-dosing.
A 6 hour level is reasonably convenient, since an inpatient having digoxin administered at 10 am can undergo venepuncture within 'office hours'. 12 hour levels are more difficult, particularly when dealing with an outpatient or patient in the community.
Has anyone come across this problem and solved it without having to do a major validation exercise?
Kind regards,
Paul Hamilton
Clinical Biochemistry
Belfast Health and Social Care Trust
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