Many thanks Edmund, great review,
So a raised GGT should be used as an alert sign to reinforce lifestyle changes vigorously, so how effective is this intervention in improving outcome?
Mohammad
--------------------------------------------
On Wed, 6/1/16, Lamb Edmund (EAST KENT HOSPITALS UNIVERSITY NHS FOUNDATION TRUST) <[log in to unmask]> wrote:
Subject: RE: Gamma GT & all casue mortality
To: "Mohammad Al-Jubouri" <[log in to unmask]>, "[log in to unmask]" <[log in to unmask]>
Date: Wednesday, 6 January, 2016, 15:04
see Annals on-line first for a recent
review
Review Article:
Sudha Bulusu andManisha Sharma
What does serum γ-glutamyltransferase tell us as a
cardiometabolic risk marker?
Ann Clin Biochem 0004563215597010, first published on July
2, 2015 as doi:10.1177/0004563215597010
http://acb.sagepub.com/content/early/2015/07/29/0004563215597010.full.pdf+html
Dr Edmund Lamb PhD FRCPath
Consultant Clinical Scientist (Biochemistry) and Head of
Clinical Biochemistry,
East Kent Hospitals University NHS Foundation Trust,
Kent and Canterbury Hospital, Ethelbert Road, Canterbury,
Kent CT1 3NG, UK
Tel: (44) 01227 864112 (direct)
Tel: (44) 01227-766877 extn 7224112
Fax: (44) 01227-783077
E-mail: [log in to unmask]
eGFR-C Study Chief Investigator: eGFR-C Study
Editor-in-Chief, Annals of Clinical Biochemistry,
journal http://acb.sagepub.com/
submissions http://mc.manuscriptcentral.com/acb
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]]
On Behalf Of Mohammad Al-Jubouri
Sent: 06 January 2016 14:26
To: [log in to unmask]
Subject: Re: Gamma GT & all casue mortality
Thanks Michael,
We have done the same from Monday 4th January 2016, but one
of the GP leads has pointed to this novel use of GGT.
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP Edin,
FRCPath Consultant Chemical Pathologist
--------------------------------------------
On Wed, 6/1/16, Colley, Michael <[log in to unmask]>
wrote:
Subject: Re: Gamma GT & all casue mortality
To: [log in to unmask]
Date: Wednesday, 6 January, 2016, 14:24
At the request of our Hepatologists /
gastroenterologists we have, starting today, removed
GGT from our LFT panel.
We await the result.
Michael
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]]
On Behalf Of Mohammad Al-Jubouri
Sent: 06 January 2016 14:21
To: [log in to unmask]
Subject: Gamma GT & all casue mortality
Dear List members,
High GGT even at upper reference limit has been reported
to be associated with risk of increased all cause
mortality as well as cardiovascular, type 2 diabetes
and cancer mortality, see this meta-analysis:
http://www.tandfonline.com/doi/full/10.3109/10715762.2014.902055
Is there enough evidence to justify its routine
measurement as part of routine LFT profile? And if
elevated what intervention the clinician could
instigate to reduce risk of mortality?
I am not a fan of GGT because of its high sensitivity
and low specificity but would welcome a debate on this
novel use of GGT.
Best regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP
Edin, FRCPath Consultant Chemical Pathologist
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