Dear List members,
High GGT even at upper reference limit has been reported to be associated with risk of increased all cause mortality as well as cardiovascular, type 2 diabetes and cancer mortality, see this meta-analysis:
http://www.tandfonline.com/doi/full/10.3109/10715762.2014.902055
Is there enough evidence to justify its routine measurement as part of routine LFT profile? And if elevated what intervention the clinician could instigate to reduce risk of mortality?
I am not a fan of GGT because of its high sensitivity and low specificity but would welcome a debate on this novel use of GGT.
Best regards
Mohammad
Dr. M A Al-Jubouri, MB ChB, MSc, EurClinChem, FRCP Edin, FRCPath
Consultant Chemical Pathologist
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