Dear all
I would be very grateful for your input regarding this case-
An 80 y old male admitted to hospital with left swollen leg and was confirmed to have a left fem-popliteal DVT . Among work-up for him was a CT abdomen which showed small amount of intra-abdominal free fluid and moderate lymphadenopathy especially in the upper abdomen. Possibly representing some form of low grade lymphoproliferative disorder rather than lymphadenopathy from a solid tumour. This was then followed by a CT thorax and a panel of tumour markers. CT thorax showed probable enlarged, para-oesophageal mediastinal lymph node and no other significant thoracic findings. All tumour markers were within ref ranges except for CEA which was >1500 ng/ml, >15000 ng/ml with 1:10 on board dilution, 18024ng/ml with 1:20 manual dilution and 10725ng/ml with 1:100 manual dilution (all tumour markers are analysed on Abbott Architect). I am just wondering if anyone had seen a significant increase in serum CEA in lymphoproliferative disease? Could this be interference in this assay if we take in consideration the 1:100 which was confirmed on repeats?
Many thanks
Soha
Dr Soha Zouwail
Consultant Chemical Pathology
University Hospital of Wales
------ACB discussion List Information--------
This is an open discussion list for the academic and clinical community working in clinical biochemistry.
Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
Green Laboratories Work
http://www.laboratorymedicine.nhs.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/
|