CCGs will approve of head in the sand because they will be able to
refuse expenditure on a greater number of patients...
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Prof. Tim Reynolds
Consultant Chemical Pathologist / Divisional Medical Director (CH&CSS) /
R&D Lead,
Burton Hospitals NHS Foundation Trust
work tel: 01283 511511 ext 4035
work fax: 01283 593064
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Iversen Andrew
(BRIGHTON AND SUSSEX UNIVERSITY HOSPITALS NHS TRUST)
Sent: 22 May 2015 2:34 PM
To: [log in to unmask]
Subject: Anti-Mullerian Hormone - Implementing the NICE cut off for NHS
fertility treatment
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Now that AMH can be automated with Roche and other systems, the numeric
value of AMH results will drop. Has anyone recalculated the NICE
guidance cut off for offering NHS fertility treatment to adjust for the
assay change?
Options include
(a) head in the sand - just use the NICE limit >5.4 pmol/L - but fewer
patients will be treated due to the lower answers from the new assay
(b) just use the 10th centile with better data - does not match NICE
guidance
(c) Use Roche best estimate >4.9 pmol/L - no direct comparison, but if
you read between the lines might be about right
(d) Use a double regression from Gen1 to Gen2 to Roche >4.1pmol/L -
double regression errors on limited data
Has anyone got a plan (e) as (a) to (d) are not that great? I think (c)
is the best of a suboptimal bunch so far.
Kind regards
Andrew
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