Thank you all for your generous help and excellent references. I will be sure to share anything that I end up writing on this subject. David Braunholtz raises some interesting issues in his BMJ piece. There’s lots of material here to chew on. Thanks!
best,
Christie
On Dec 2, 2014, at 10:21 AM, Work-related <[log in to unmask]> wrote:
> We looked at the underlying ethical considerations in a brief article a while ago, and came to the (controversial !) conclusion that in general DMCs should publish interim findings, and leave it to clinicians / patients to decide whether to continue to enrol based on the available info, rather than the DMCs (paternalistically) stop (or not) trials themselves. Think it is fair to say this was not a popular view amongst trialists - but suspect most patients might have a different view ?
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> Lilford et al. BMJ. Aug 25, 2001; 323(7310): 441–442. Monitoring clinical trials—interim data should be publicly available
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> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1121037/
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