On 7/23/2014 9:39 AM, Poses, Roy wrote:
> I still don't see why case-series without any control groups are now
> regarded as credible ways to evaluate efficacy of therapy???
I cannot comment on this particular example, but in general you can
safely dispense with a control group when there is close to 100%
morbidity or mortality in that control group. In such a setting, any
improvement is painfully obvious and does not need a rigorous design or
fancy statistical analysis. Also, it is pretty difficult and probably
unethical to randomly assign half your patients to be in a group that
has 100% morbidity or mortality.
Steve Simon, [log in to unmask], Standard Disclaimer.
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