Hello Nicola,
see this reference - although it is a study in paediatric children.
S. Ghazali and T. M. Barratt (1997). Urinary excretion of calcium and magnesium in children
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1648734/
We suggest a 24 hour urine sample as many times the random urine calcium excretion ratio were in the intermediate range. See other refs here:
Jayasena et al, Utility of the urine calcium-to-creatinine clearance ratio to diagnose primary hyperparathyroidism in asymptomatic hypercalcaemic patients
with Vitamin D Deficiency, Annals of Clinical Biochemistry, 2011, 48: 126-129, and references within
Kind regards,
Funmi Akinlade
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Nicola Pullan
Sent: 03 July 2013 11:30
To: [log in to unmask]
Subject: Urine sample for PHPT vs FHH
Dear Mailbase,
Can anyone explain the origin of the "fasting, second-void" urine sample for the assessment of familial benign hypercalcaemic hypocalciuria vs primary hyperparathyroidism?
Particularly, why is it recommended that the sample is second-void rather than just fasting?
Do any labs/endocrinologists recommend anything other than this when trying to distinguish between primary hyperparathyroidism and FHH?
Best wishes,
Nicola
Nicola Pullan
Clinical Scientist - Biochemistry
Pathology Sciences Laboratory
Southmead Hospital
Westbury on Trym
Bristol, BS10 5NB
Email: [log in to unmask]
Tel: 0117 32 38514
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