Hi Catherine,
Please see, for example:
The fading of reported effectiveness. A meta-analysis of randomised controlled trials
Bernhard T Gehr, Christel Weiss and Franz Porzsolt
BMC Medical Research Methodology 2006, 6:25
http://www.biomedcentral.com/1471-2288/6/25
Kind regards,
Michele
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Michele Hilton Boon | Programme Manager, Standards & Indicators
Healthcare Improvement Scotland
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-----Original Message-----
From: Evidence based health (EBH) [mailto:[log in to unmask]] On Behalf Of Catherine Meads
Sent: 13 May 2013 10:20
To: [log in to unmask]
Subject: Re: EVIDENCE-BASED-HEALTH Digest - 11 May 2013 to 12 May 2013 (#2013-120)
Hi. Does anyone have anything on how estimates of treatment effects can change over time. In particular I'm looking for where there is a strong negative trend, with the relative risk reduction starting out very high but dropping as information from successive trials becomes available. Or the opposite. If you could point me to any recent publication on this I would be grateful. In particular a summary of cumulative meta-analyses across different interventions.
Many thanks Catherine
Dr Catherine Meads
Reader in Health Technology Assessment,
Health Economics Research Group,
Brunel University,
Room 060 Gaskell Building, Uxbridge, Middlesex, UB8 3PH, UK.
Tel 01895 265242
email [log in to unmask]
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