Michael,
This is the pointy end of the different assays.
Any method comparison (especially TnT and TnI) which measure similar but
not identical molecules will do this. Any TnT v TnI comparison shows the
scatter near the decision point. I recall meeting with our cardiologists
when considering a change from Centaur TnI ultra to 4th gen TnT. I said
the sensitvity and specificity were the same (sighs of relief), but some
of the patients you sent home last week you would now keep, and some of
the patient's you kept in last week you would now discharge (not so
happy).
I would belive the more sensitive assay.
Regards,
Graham
>>> "Colley, Michael" <[log in to unmask]> 05/22/13 2:10 AM >>>
A post-op patient at the local private hospital had a twinge of pain, so
a Troponin T was performed by TDL (who do the Path for them). The value
of 17 was obtained (ULN 14) so he was sent to Great Western as a
potential cardiac patient.
A further sample was analysed at GWH and the Trop I was 20 (ULN 40 ) so
he was, eventually discharged.
In an attempt to clarify, the GWH sample was send to TDL, who analysed
it for TropT – again getting 17 (on two different analysers) and for
Trop I – again getting 20.
So the question is "has the patient got myocardial damage?" as per Trop
T or hasn't he as per Trop I.
Michael
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