It is probably the only assay where they have looked!
Most assays using a biotin-avidin linkage system will have a similar
interference - but the manufacturers have been careful not to look...
The same sort of issue affects statins: Rosuvastatin can only be used in
asians in half the caucasian dose because of a drug metabolism effect.
Have the other drug compoanies done similar tests? It's doubtful because
if they had they would have been using the data in marketing - they have
simply buried their heads in the sand and been careful not to look too
far beneath the surface...
************************************************************************
**************
Prof. Tim Reynolds
Consultant Chemical Pathologist / Clinical Director - Diagnostics / R&D
Lead,
Burton Hospitals NHS Foundation Trust
work tel: 01283 511511 ext 4035
work fax: 01283 593064
work email: [log in to unmask]
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Gerald Cox
Sent: 08 May 2013 4:44 PM
To: [log in to unmask]
Subject: Roche crosslaps assay
A recent urgent field safety notice arrived stating a reducded stability
from 8 hrs to 6 hrs for serum and a reduced level biotin interference,
from 368 nmol/L to 123 nmol/L. My question is how do we know who is on
biotin and who measures biotin routinely?
Second question is why is it only beta crosslaps the only immunoassay
affected?
Thanks
Gerry
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