Mauricio:
I look forward to Ken's thoughtful response, but before reading it I want to comment that I took Jacob to be saying NOT that a large N and a small p are bad in academic OR in clinical research, but rather that he was arguing a larger point about the danger in drawing too many general conclusions from a single narrowly focused study no matter how large the N or small the p.
I took Jakob's article as both a call for better research study design using well-diversified populations for example, AND as a call for more research programs in design, investigating related issues, in more places, doing rigorous work, whose methods are comparably sound and whose results can be profitably compared with each other to get a fuller, more valid and more reliable understanding. In my mind it was more high quality studies each with appropriately high N's and small p's that Jakob's article suggested.
Mike Zender
Professor, Director, Graduate Program in Design
University of Cincinnati
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