Dear colleagues,
We have an interesting case of hypernatraemia (168mmol/L) in a young female patient with normal renal function. The result confirmed on a second and third Roche Cobas 8000 indirect ISE module. When this sample was analysed by direct ISE the result was fairly normal (149 mmol/L). All analysis was carried out on the same primary tube.
Clinically the 149 mmol/L value seems more appropriate and we have added serum osmolality, total protein and chloride to further investigate. We're suspicious that something may be interfering in the indirect method. Is anyone aware of any potential causes for this pattern, or has observed this effect before?
Thanks
Jen
Jennifer Glaysher
Principal Clinical Scientist and Pre-Analytics Supervisor
Aintree University Hospitals NHS Trust
Longmoor Lane
L9 7AL
Phone: 0151 529 3990
Laboratory handbook: http://nww.ahtpathology.nhs.uk
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