Would you be able to measure free phenytoin?
The link below may aslo help
http://clincalc.com/Phenytoin/Correction.aspx
Best Regards
Mohamed
On Wed, 16 Jan 2013 15:49:06 +0000
"Vickery Susan (EAST KENT HOSPITALS UNIVERSITY NHS FOUNDATION TRUST)" <[log in to unmask]> wrote:
>Dear Mailbase,
>
>We have had an enquiry from a pharmacist to see if we can provide phenytoin results that have been corrected for albumin concentration.
>
>The rationale being that there was a recent case where the phenytoin concentration was 10 mg/L and the albumin concentration was 24 g/L. The corrected phenytoin concentration was 20 mg/L, but the dose of phenytoin was increased because the clinician used the uncorrected value of 10 mg/L. It resulted in the patient becoming toxic. Our pharmacist feels patient safety would be improved if corrected phenytoin concentrations were reported and has provided us with the equation to do this.
>
>Does anybody have experience of correcting phenytoin concentrations? Are there any risks in doing this? Finally, what equations, to correct for albumin concentration, are being used?
>
>Thoughts and comments welcome.
>
>Regards,
>Susan.
>
>Dr Susan Vickery
>Department of Laboratory Medicine
>East Kent Hospitals University NHS Foundation Trust
>
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