Dear all,
We recently had a case of a 24 year old female GP patient with a testosterone result of 11.8 nmol/L (run on a Roche Elecsys E170 Modular system).
Her GP subsequently contacted us saying that the patient was due to start taking norethisterone (a synthetic progestogen) but may have started prior to the bloods being taken. A repeat sample was sent 4 weeks later (10 days off treatment) which gave a testosterone result of 0.5 nmol/L.
Roche provided us with information from their spiking experiments showing a cross-reactivity of 5%. UKNEQAS also carried out a spiking experiment in distribution 379 which showed that the Roche platform performed with a significant positive bias.
Has anyone else come across similar cases where norethisterone has given such dramatically elevated testosterone results?
Any information greatly appreciated.
Best wishes,
Nick Unsworth
Trainee Clinical Scientist
Clinical Biochemistry, UCLH
60 Whitfield Street
London
W1T 4EU
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