Paolo,
I know this is not helpful but the obvious solution would be: if you are
interested in looking at a small region of the brain, then you should
collect high-resolution fMRI data. Whatever you do during spatial
normalization, your original resolution will basically be the best you
can achieve: there is not more information inherent in the data you
have. There was a paper in NeuroImage (PMID 11467900) in 2001 where the
Göttingen group looked at what you need to do fMRI of the amygdala, and
they concluded "Although high-resolution BOLD MRI is at the expense of
temporal resolution and volume coverage, it seems to provide the only
solution to this physical problem." Many things have changed since then,
but I would still second that.
Good luck,
Marko
Paolo Taurisano wrote:
> Dear SPMers
>
> I should performan fMRI study to investigate a very small area such as
> the lateral geniculum body. Currently I acquire a voxel size of 3.75
> x3.75x5 and normalize it into 2x2x2 voxel in spm. I'm worried about not
> being able to catch the signal from such a small area. I should adopt
> special procedures in the process of normalization?
>
> Many thanks in advance
>
> Paolo
>
--
____________________________________________________
PD Dr. med. Marko Wilke
Facharzt für Kinder- und Jugendmedizin
Leiter, Experimentelle Pädiatrische Neurobildgebung
Universitäts-Kinderklinik
Abt. III (Neuropädiatrie)
Marko Wilke, MD, PhD
Pediatrician
Head, Experimental Pediatric Neuroimaging
University Children's Hospital
Dept. III (Pediatric Neurology)
Hoppe-Seyler-Str. 1
D - 72076 Tübingen, Germany
Tel. +49 7071 29-83416
Fax +49 7071 29-5473
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http://www.medizin.uni-tuebingen.de/kinder/epn/
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