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Paolo, I know this is not helpful but the obvious solution would be: if you are interested in looking at a small region of the brain, then you should collect high-resolution fMRI data. Whatever you do during spatial normalization, your original resolution will basically be the best you can achieve: there is not more information inherent in the data you have. There was a paper in NeuroImage (PMID 11467900) in 2001 where the Göttingen group looked at what you need to do fMRI of the amygdala, and they concluded "Although high-resolution BOLD MRI is at the expense of temporal resolution and volume coverage, it seems to provide the only solution to this physical problem." Many things have changed since then, but I would still second that. Good luck, Marko Paolo Taurisano wrote: > Dear SPMers > > I should performan fMRI study to investigate a very small area such as > the lateral geniculum body. Currently I acquire a voxel size of 3.75 > x3.75x5 and normalize it into 2x2x2 voxel in spm. I'm worried about not > being able to catch the signal from such a small area. I should adopt > special procedures in the process of normalization? > > Many thanks in advance > > Paolo > -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn/ ____________________________________________________