Maurice,
I have seen one patient who had lung and heart transplant on ciclosporin, where cholesterol increased from a baseline of 5.6 mmol/l to 11.2 mmol/l over a period of 4 months.
Best wishes
Peter
Dr Peter Sharpe
Consultant Chemical Pathologist
Director of Research and Development
Southern Health & Social Care Trust
Ext 2657
Tel 028 38612657
Fax 028 38334582
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of OKane, Maurice
Sent: 05 December 2011 14:25
To: [log in to unmask]
Subject: Ciclosporin /cholesterol
Dear all,
I have been referred a young patient with inflammatory bowel disease who had an initial cholesterol of 6 mmol/L which increased to 9mmol/L within 24h of starting ciclosporin and rose further over the next week, currently is at 12mmol/L. Triglycerides are minimally elevated at 2.5mmolL, HDL 1 mmol/L. No other secondary cause : normal glycaemia, thyroid, no proteinuria, no alcohol. There is mild AST/ALT increase only. There are no lipid results available from before she developed IBD. There is nothing in personal or family history to suggest Familial hypercholesterolaemia [i.e. might the pre-ciclosporin cholesterol have been spuriously low for that patient as part of a negative acute phase reaction which then increased as her IBD came under control?]
Ciclosporin is a well recognised cause of dyslipidaemia, but I have never seen anything to this degree. Also the almost immediate rise [within 24 hours] is unusual.
Any thoughts?
thanks
Maurice
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