We are looking for an ambitious and highly-motivated postdoctoral research associate who has expertise in protein crystallography to join the team of Dr Richard Bayliss within the Department of Biochemistry. The position is funded by a 5-year Cancer Research UK Programme Grant, which provides a generous allowance for equipment, running costs and research support.

Research in the Bayliss lab is focussed on the structural mechanisms by which cell division is regulated, and on the structure-based design of chemotherapeutics. The group has built an international reputation for excellence in these fields, and has published 10 papers in peer-reviewed journals in the past 3 years.

The main objective of this new position will be to elucidate the regulatory mechanisms of separase, the protease that triggers chromosome segregation. This is a high-impact project that will address a long-standing, unresolved question in mitosis and which is supported by several years of pilot work. The researcher will also contribute to the other aspects of the programme, such as the pathways of regulation by protein kinases (Aurora-A, Neks) and the early prophase checkpoint (CHFR). 

Dr Bayliss’s research group is located in the state-of-the-art Henry Wellcome Building with access to excellent facilities for biochemical studies, structural biology, cell culture (including large-scale insect and mammalian cell expression), microscopy and computer analysis. The position is available from January for three years in the first instance, renewable for a further two years depending on progress. The appointment will be made within the salary range £30,870 - £35,788. Prospective candidates should hold a degree and Ph.D in biochemistry, or related discipline, and have proven expertise in X-ray crystallography through the publication of at least one first author paper in a major international journal. 

Informal enquiries can be directed to Dr Bayliss via email ([log in to unmask]). Applications must be made through the Job Vacancies page of the University website, job reference MBP00499.

The closing date for this post is midnight on 6th December 2011.





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Dr Richard Bayliss, Reader in Structural Biology 
Department of Biochemistry
Henry Wellcome Building
University of Leicester
Lancaster Road, Leicester
LE2 9HN

Tel: 0116 2297100
Web: http://www2.le.ac.uk/departments/biochemistry/staff/richard-bayliss/