In our laboratory we are having a problem with Calcium from Roche
Diagnostics. Until recently, we have been analysing calcium on ModP
and Cobas 6000 (c501). Annual checks with normal volunteers has
demonstrated that our reference range is within 2.10 - 2.55 mmol/L. At
this moment, we are making the switch towards c701 (Cobas 8000). Our
initial validation between ModP/c501 and c701 showed higher calcium
results (about 0,06 mmol/L). However, in a recent Important Notice
(august 2011) for Calcium, Roche has published a new assigned value
for our Cfas lot from 2.61 mmol/L to 2,64 mmol/L. After this
adaptation of the Cfas target, we noticed that in average our patient
results further increased with 0.08 mmol/L. Together, this makes 0,14
mmol/L (0.06 + 0.08). Consequently, if we make this switch, this will
result in quite a lot of hypercalcemic patients in our hospital.
I have informed Roche about this discrepancy in results between
ModP/c501 and c701. The information that I have received about this
complaint is the following:
"GCS is aware of the different recoveries for calcium on c 701
compared with those on ModP or c501. The reason therefore is the
reference standardization of calcium which leads to the fact that we
had to provide a target value assignment for cobas c 701 which
furthermore leads to increased values. In the future we will also
provide a target value assignment for cobas c 501 and Mod P which
leads to increased values as well."
Is someone experiencing the same problem on c701?
Kind regards,
Veronique Stove
Veronique Stove, Pharm, PhD
Clinical biologist
Ghent University Hospital
De Pintelaan 185, 2P8
9000 Gent
Belgium
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