Hi Grainne,
If you have access to a recording spectrophotometer, it may be helpful to
scan the sample (some dilution will be required).
Then inspect the scan carefully, especially near the wavelengths used on
your Roche analyser to calculate the lipaemic index, and also the direct
bilirubin results.
What was the total bilirubin result?
What sample type was used (eg serum or plasma). Gel tube or no gel?
Have you assayed the sample by a different method?
Michael Peake
(retired)
Biochemistry Department
Flinders Medical Centre
Bedford Park
South Australia
08-84 43 3332
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Connolly, Grainne
Sent: Saturday, 16 July 2011 2:17 AM
To: [log in to unmask]
Subject:
Hi all,
We would be grateful for any thoughts on the following case. There is a
baby in our neonatal ICU with multiple medical problems who has a high
bilirubin. On our Roche method we have been unable to report a direct
bilirubin due to a high lipaemic index (index 130). However on inspection
of the sample it is not lipaemic and triglycerides are 0.79. We have
centrifuged the sample, there is no lipid and the results (including the
indices) are unchanged. The baby also has had no lipid for the last 3 days
and the lipaemic index has held at this level.
Has anyone any suggestions as to what may be interfering or causing the
lipaemic index?
Many thanks,
Grainne
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