According to the ESC guidelines (2008), the therapeutic serum concentration should be between 0.6 and 1.2 ng/mL, and "there is no evidence that regular digoxin concentration measurements confer better outcomes"
http://www.escardio.org/guidelines-surveys/esc-guidelines/Pages/acute-chronic-heart-failure.aspx
Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
Laboratoire de Biologie Polyvalente
Centre Hospitalier La Chartreuse
Avenue Caylet
12200 Villefranche-de-Rouergue
France
--- En date de : Mar 21.6.11, Hallworth Mike (RLZ) <[log in to unmask]> a écrit :
> De: Hallworth Mike (RLZ) <[log in to unmask]>
> Objet: Re: Digoxin
> À: [log in to unmask]
> Date: Mardi 21 juin 2011, 15h04
> Excellent - welcome news. Is a
> revised chart to be produced and sent to
> relevant organizations? The one on the RCPath website is
> still the old
> version.
>
> Mike
>
> (and, at the risk of being thought a pedant, may I point
> out once again
> that for TDM analytes these are not RRs. They are target
> ranges, which
> are not the same!).
>
> -----Original Message-----
> From: Clinical biochemistry discussion list
> [mailto:[log in to unmask]]
> On Behalf Of Sally Brady
> Sent: 21 June 2011 13:59
> To: [log in to unmask]
> Subject: Fwd: Digoxin
>
> Dear All,
>
> I don't know if you're aware but the Pathology Harmony RR
> for Digoxin
> has been extended since it was announced in the ACB news.
> See below.
>
> Sally
>
>
>
> Dr Sally Brady
> Clinical Biochemist
> Blood Sciences
> The Hillingdon Hospital
> 01895 279924
>
>
> >>> "Coley-Grant Deon (THE ROYAL WOLVERHAMPTON
> HOSPITALS NHS TRUST)"
> <[log in to unmask]>
> 21/06/2011 09:57 >>>
> Hi Sally,
>
>
>
> I can confirm that there has been an amendment to the
> digoxin RR.
>
>
> The digoxin reference interval generated a lot of
> discussion and brought
> forward many concerns. At the last Harmony Meeting
> held 10th May we
> reviewed the proposed RR, and decided that we should extend
> the proposed
> range to 0.5 - 2.0 ug/L. It was recommended that a
> mandatory comment
> such "Target range in heart failure 0.5 -
> 1.0 ug/L" is added to the
> report.
>
> I hope this helps,
>
> Best regards,
> Deon
>
>
>
> Deon Coley-Grant
> Principal Clinical Scientist
> Clinical Chemistry Dept
> New Cross Hospital
> 01902 307999 extn 8261
>
>
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