Would be nice if NICE would also issue a caution such as :
Please note non-specificity of CA-125
Also may be raised in :
pregnancy, menstruation, endometriosis, ascites,
cirrhosis, renal failure, acute pancreatitis,
peritonitis, PID.
I also wonder if Mr/Ms Nice has seen Eric Kilpatrick's
http://www.bmj.com/content/339/bmj.b3111.full
which includes :
".... none of the commonly requested tumour markers related to gastrointestinal and gynaecological disease (CEA, CA19.9, and CA125) is recommended for screening for cancer, and most expert groups also recommend against using them in the initial investigation of a patient who has symptoms. As a screening tool, the positive predictive value (PPV) of a raised CA125 concentration is estimated to be 2.3%, requiring 50 women to undergo laparoscopy or laparotomy for one ovarian cancer to be detected
Or
Sturgeon's paper
BMJ 2009; 339:b3527 doi: 10.1136/bmj.b3527 (Published 22 September 2009)
http://www.bmj.com/content/339/bmj.b3527.extract
with best wishes
Richard
Richard Mainwaring-Burton
Consultant Biochemist
Queen Mary's Hospital
Sidcup, Kent
020-8308-3084
South London Healthcare NHS Trust
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Douglas Thompson
Sent: 27 April 2011 09:42
To: [log in to unmask]
Subject: Re: Simple blood test could save hundreds from ovarian cancer - Health News, Health
For those of you who may wish to look at the final NICE guideline it can be found at:
http://guidance.nice.org.uk/CG122/QuickRefGuide/pdf/English
Best wishes
Douglas
Dr D Thompson
Blood Sciences
The General Infirmary
Leeds LS1 3EX
Tel 0113 3926503
Please visit our web-site at www.leedsteachinghospitals.com
>>> Reynolds Tim <[log in to unmask]> 27/4/11 08:21 >>>
But no mention of the thousands who would face unnecessary
investigations for false positive results...
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Jonathan Kay
Sent: 27 April 2011 00:39
To: [log in to unmask]
Subject: Simple blood test could save hundreds from ovarian
cancer - Health News, Health
http://www.independent.co.uk/life-style/health-and-families/health-news/
simple-blood-test-could-save-hundreds-from-ovarian-cancer-2275152.html
Jonathan
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