Has anyone seen this problem with IM dexa?
John
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Darby Denise (Christie Hospital NHS Foundation Trust)
Sent: 04 November 2010 21:12
To: [log in to unmask]
Subject: Re: Creatinine assay interference ?
Before we realised what was the cause of the problem we had checked the result, using both O'Leary and enzymatic assays. The problem isn't really analytical interference - the assay is simply measuring the increased creatinine which has just been administered to the patient intravenously along with the dexamethasone.
Regards
Denise
________________________________________
From: Indovina, Joe [OCDUS] [[log in to unmask]]
Sent: 04 November 2010 20:51
To: Darby Denise (Christie Hospital NHS Foundation Trust); [log in to unmask]
Subject: RE: Creatinine assay interference ?
What type of creatinine assay is being used?
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Denise Darby
Sent: Thursday, November 04, 2010 4:44 PM
To: [log in to unmask]
Subject: Re: Creatinine assay interference ?
Dear All
We have also recently just had a case of creatinine interference following IV dexamethasone despite not previously experiencing such problems.
Discussion with pharmacy revealed that they have recently changed supplier to Hospira UK LTD which contains creatinine as an excipient unlike the previous brand we were using. Pharmacy suggested that there are problems nationwide with supply of the previous brand and most of the country is now using the Hospira brand. It might be worth checking with your pharmacy to see if they have also recently changed suppliers.
Regards
Denise
Denise Darby
Consultant Chemical Pathologist
The Christie, Manchester
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