Hi Ze
> I have a hard time to understand modulation for voxel wise tissue
> intensity comparisons. Let's say sub A's hippocampus is half size of sub B,
> but they have the same intensity. So if our focus is to check whether the
> intensity of hipp is different between A and B, should the modulation be
> avoided? otherwise, modulation will result in a spurious intensity
> difference in the whole hippocampus.
That's right...and presumably why the default for functional analyses
has always been not to modulate during normalization.
Best regards,
Jonathan
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