Dear VBMers,
I have a hard time to understand modulation for voxel wise tissue
intensity comparisons. Let's say sub A's hippocampus is half size of
sub B, but they have the same intensity. So if our focus is to check
whether the intensity of hipp is different between A and B, should the
modulation be avoided? otherwise, modulation will result in a spurious
intensity difference in the whole hippocampus.
I revisited this issue since the similar situation will happen to
CBF map normalization and group level comparisons.
Any thoughts?
Thanks
Ze
|