I use PISA to analyse this - sometimes the differences depend on the
definition of "what is a hydrogen bond?" and unless you have very high
resolution it is risky to say there are significant differences.. But
certainly there are examples where the results are very significant
indeed - you could look at the extensive heamoglobin literature..
Eleanor
Roger Rowlett wrote:
> I don't think this is uncommon at all. For example, we published a structure
> where 10 chains did not bind ligand at all, and 2 chains did in the ASU (see PDB
> 3E3I). We have also recently solved a structure where two active sites in the
> ASU are in different states.
>
> Cheers.
>
> On 9/8/2010 12:50 PM, Rongjin Guan wrote:
>> Dear All,
>>
>> I have a structure with two complexes in the asymmetric unit, and the interactions
>> on the interface are not the same in the two complexes. Briefly, there are two
>> additional
>> hydrogen bonds in one complex, but not in the other. This coule be due to
>> crystallization
>> artefact, but may have other explanations.
>>
>> Can anyone direct us to some references where this has been discussed before?
>>
>> Thank you very much
>>
>> Rongjin Guan
>>
>>
> --
> --------------------------------------------------------------------------------
> Roger S. Rowlett
> Professor
> Department of Chemistry
> Colgate University
> 13 Oak Drive
> Hamilton, NY 13346
>
> tel: (315)-228-7245
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