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I use PISA to analyse this - sometimes the differences depend on the definition of "what is a hydrogen bond?" and unless you have very high resolution it is risky to say there are significant differences.. But certainly there are examples where the results are very significant indeed - you could look at the extensive heamoglobin literature.. Eleanor Roger Rowlett wrote: > I don't think this is uncommon at all. For example, we published a structure > where 10 chains did not bind ligand at all, and 2 chains did in the ASU (see PDB > 3E3I). We have also recently solved a structure where two active sites in the > ASU are in different states. > > Cheers. > > On 9/8/2010 12:50 PM, Rongjin Guan wrote: >> Dear All, >> >> I have a structure with two complexes in the asymmetric unit, and the interactions >> on the interface are not the same in the two complexes. Briefly, there are two >> additional >> hydrogen bonds in one complex, but not in the other. This coule be due to >> crystallization >> artefact, but may have other explanations. >> >> Can anyone direct us to some references where this has been discussed before? >> >> Thank you very much >> >> Rongjin Guan >> >> > -- > -------------------------------------------------------------------------------- > Roger S. Rowlett > Professor > Department of Chemistry > Colgate University > 13 Oak Drive > Hamilton, NY 13346 > > tel: (315)-228-7245 > ofc: (315)-228-7395 > fax: (315)-228-7935 > email: [log in to unmask]