Isnt the problem one of interpretation? If you use a provocative test,
it seems odd to use the standard non-challenged reference range.
Gareth
Gareth Llewelyn ap Huw Jones
Principal Clinical Scientist
Clinical Biochemistry UCLH
3rd Floor, 60 Whitfield Street
London W1T 4EU
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Nick Miller
Sent: 09 September 2010 10:27
To: [log in to unmask]
Subject: Re: alternative paractitioners anda heavy metal poisoning
I don't agree with Stephen Barrett that challenge tests followed by
urine analysis are an invalid way of testing for excess metal
sequestration. It is biologically a perfectly plausible approach and may
be useful in cases where, for one reason or another, blood levels fail
to elucidate the problem. I have personally more than 30 years
experience of analysing the results from such tests, starting with EDTA
provocation for lead (which was recomended and used by Trevor Delves, no
less) - so don't be put off so easily.
Analysis of metals has improved considerably over the years due to the
availability of ICPMS and the sterling work of the TEQAS scheme. There
are however still some pretty odd results around - and results for
elements in urine can be difficult to interpret at the best of times
since for many metals it is not the normal route of excretion.
Urine is, however, the specimen of choice for assessing nickel exposure
(see "Handbook of the toxicology of metals" ed.Nordberg GF et al, 3rd
edition Academic Press 2008, chapter 35 page 743 - 758).
I know it is much easier to click on the web and ingest the rantings of
an American neo-conservative, but I recomend the traditional route of
looking at a "proper" academic text and thinking about the question.
Nick Miller
London
On 9 September 2010 09:35, COLLINS MICHAEL (RM1) Norfolk and Norwich
University Hospital <[log in to unmask]> wrote:
> http://www.quackwatch.com/01QuackeryRelatedTopics/Tests/urine_toxic.ht
> ml
>
>
> Mike Collins
> BMS3
> Biochemistry Automation
> Norfolk & Norwich University Hospital
> England
> [log in to unmask]
> http://www.nnuh.nhs.uk/
>
>
> -----Original Message-----
> From: Clinical biochemistry discussion list
> [mailto:[log in to unmask]] On Behalf Of Ryan, Michael
> Sent: 08 September 2010 17:05
> To: [log in to unmask]
> Subject: alternative paractitioners anda heavy metal poisoning
>
> Dear All,
>
> I have patient with bizaare symptoms who has been tested by an
alternative practitioner who sent samples to a laboratory in Germany.
The patient is now convinced she has lead, palladium, and nickel
poisoning. She was initially treated with 'chelating agents' at synergy
healthcare, and the urinary mineral analysis was carried out by
Microtrace Minerals Gmbh.
>
> The levels of these metals appear to be within acceptable limits for
the UK. The results are reported as 21.93ug/g creatinine (lead),
6.85ug/g creatinine (Nickel) and 2.05 ug/g creatinine (palladium) in a
spot urine sample (0.3g creatinine per litre).
>
> All advice gratefully received.
>
> Michael Ryan
>
>
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