Dear colleagues,
You may wish to consult the following review article
Acta Neurochir (Wien). 2010 Jan;152(1):1-17. Epub 2009 Aug 4.
Update on protein biomarkers in traumatic brain injury with emphasis on
clinical use in adults and pediatrics.
Kövesdi E, Lückl J, Bukovics P, Farkas O, Pál J, Czeiter E, Szellár D,
Dóczi T, Komoly S, Büki A.
Department of Neurosurgery, University of Pécs, Rét u. 2., 7623, Pécs,
Hungary.
Abstract
PURPOSE: This review summarizes protein biomarkers in mild and severe
traumatic brain injury in adults and children and presents a strategy for
conducting rationally designed clinical studies on biomarkers in head
trauma. METHODS: We performed an electronic search of the National Library
of Medicine's MEDLINE and Biomedical Library of University of Pennsylvania
database in March 2008 using a search heading of traumatic head injury and
protein biomarkers. The search was focused especially on protein
degradation products (spectrin breakdown product, c-tau,
amyloid-beta(1-42)) in the last 10 years, but recent data on "classical"
markers (S-100B, neuron-specific enolase, etc.) were also examined.
RESULTS: We identified 85 articles focusing on clinical use of biomarkers;
58 articles were prospective cohort studies with injury and/or outcome
assessment. CONCLUSIONS: We conclude that only S-100B in severe traumatic
brain injury has consistently demonstrated the ability to predict injury
and outcome in adults. The number of studies with protein degradation
products is insufficient especially in the pediatric care. Cohort studies
with well-defined end points and further neuroproteomic search for
biomarkers in mild injury should be triggered. After critically reviewing
the study designs, we found that large homogenous patient populations,
consistent injury, and outcome measures prospectively determined cutoff
values, and a combined use of different predictors should be considered in
future studies.
PMID: 19652904 [PubMed - indexed for MEDLINE]
--
Priv.-Doz. Dr. med. Michael Steiner
Medizinisches Labor Rostock
Suedring 81
D-18059 Rostock
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