Dear all,
It is interesting that this question is raised on the ACB forum!
Back in 1993 the "Guide to the Expression of Uncertainty in Measurements"
was published by ISO, IFCC, IUPAC etc (now available for downloading at
www.bipm.org), followed by a more extensive guide published by Eurachem
(EUROLAB Measurement uncertainty reAccessed: Alternative approaches to
uncertainty evaluation. Eurolab Technical Report No 1/2007. 2007 Jan.
www.eurolab.org). The ISO/TC 212 is currently finishing a guide adjusted to
the needs of laboratory medicine and so is CLSI. The ACB sister
organization, AACB, published "AACB National Pathology Accreditation
Advisory Council (Australia). Requirements for the Estimation of Measurement
Uncertainty (2007)
http://www.health.gov.au/internet/main/Publishing.nsf/Content/86A3CE312C6123
77CA257283007BC92D/$File/dhaeou.pdf".
The many authoritative publications illustrate the complexity of the problem
and the many opinions there are on how industry and profession should
approach the problem and find a solution that would satisfy the most urgent
needs, i.e. specifying and verifying the performance of measurement
procedures and expressing an uncertainty that is understandable and useful
in medical practice.
So rather than starting from scratch and reinventing the wheel - which would
most likely resemble one made by Flintstone - I humbly suggest that you find
out what has already been done.
Anders Kallner
Dept Clin Chem
Phone +46 8 5177 4943
Karolinska University Hospital
SE 171 76 Stockholm
Sweden
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