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We have experienced similar flier problems with our ACRs, particularly when running serum and urine samples on same instrument. Do other users run their urines in batches separate from serum?
We also have flier problems with our Calcium assay.
On the immunoassay side we have been experiencing fliers with the Troponin -- most but not all of these have been on serum (?fibrin interference) rather than plasma samples.
Mark Lynch
-----Original Message-----
From: Clinical biochemistry discussion list [mailto:[log in to unmask]]On Behalf Of Meek, John
Sent: 17 August 2009 17:10
To: [log in to unmask]
Subject: Re: Abbott Architect fliers?
Dear Ian,
We have had problems with urine albumin which have been due to reagent 2 probes. It shows up when we run urine albumin and urine creatinine together (as normally done) - if we re-run the albumins again without creatinine in between each one, then the results are OK. The explanation seems to be that "old" probes (i.e. over 3 months' usage) carry over the sodium hydroxide R2 of the creatinine method. It may well be the hydroxide reagent that does the damage to the probe. If you have creatinine on the machine(s) producing the fliers this may be the cause (or some other reagent with probe-etching properties). Pending a formal manufacturer response, we are changing probes at 2-monthly intervals.
John Meek
Hammersmith Hospital, London.
________________________________
From: Clinical biochemistry discussion list [mailto:[log in to unmask]] On Behalf Of Ian Barlow
Sent: 17 August 2009 15:22
To: [log in to unmask]
Subject: Abbott Architect fliers?
Dear colleagues,
Periodically we get IgM, and more recently, caeruloplasmin "fliers" which we have attributed to "ageing" reagent probe 2.
Have any other labs experienced similar problems?
Regards
Ian Barlow
Scunthorpe
UK
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