This review:
http://www.clinchem.org/cgi/reprint/52/7/1247, about
Gc-globulin response to injury is from 2006 and gives a
large number of references.
Brian
On Mon, 15 Jun 2009 10:59:51 +0000
Joseph WATINE <[log in to unmask]> wrote:
>
> many thanks Brian,
>
> The problem that I have with this study is that it is
>quite old.
>
> Isn't there any more recently published study?
>
> Joseph
>
>> Date: Sun, 14 Jun 2009 16:48:32 +0100
>> From: [log in to unmask]
>> Subject: Re: Vitamin D over requesting
>> To: [log in to unmask]
>>
>> Thanks, Reza. A fascinating paper that will give Joseph
>> Watine an idea the extent of the decreases in vitamin D
>> that might be seen in patients. The authors had seen
>>seven
>> patients with Gc-globulin values more than 60% below
>>mean
>> normal, one of them 80% below - all seven patients were
>> severely ill.
>>
>> In one of their patients who had a sickle cell crisis
>>and
>> chest infection the Gc-globulin had fallen by 60% of the
>> admission value by the second day, but then rose from
>>60%
>> below to 50% above and remained high for two weeks. A
>> similar pattern was seen in a study of the serial
>>changes
>> in Gc-globulin in 12 patients after a standardised
>> orthopaedic operation resulting in major muscle damage
>> (Inflamm Res 2001;50:39). Total Gc-globulin fell by 87%
>> postoperatively and then rose to 35% above preop values
>>by
>> day 5, subsequently falling to preop values by day 28. I
>> suggested in my email that Gc-globulin was a negative
>> acute phase protein; these studies suggest the opposite.
>>
>> A question to which I have been unable to find an answer
>> is whether the newly synthesised Gc-globulin responsible
>> for these increases carries with it from the liver the
>> vitamin D sequestered when Gc-globulin-actin complexes
>> were removed from the circulation. If it does not, then
>> low vitamin D values might persist a lot longer after
>> tissue damage than low Gc-globulin values.
>>
>> With best wishes
>>
>> Brian
>>
>> On Fri, 12 Jun 2009 15:11:40 +0000
>> Reza Morovat <[log in to unmask]> wrote:
>> >
>> > An excellent and informative article (from the days
>>that
>> >clinical
>> > biochemists used to be able to do more basic
>>scientific
>> >research) is
>> > this:
>> >
>>http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1146295&blobtype=pdf
>> >
>> > Needless
>> > to say, the relation between an increase in total vit
>>D
>> >and its
>> > availability for conversion to 1,25 or its efficacy is
>> >not always so straight-forward,
>> > as the affinities for Gc-glob can vary by quite a bit
>> >(as also do those
>> > for intracellular vit D binding proteins, and that for
>> >1,25 binding to
>> > its receptor(s) - not to mention the regulation of the
>> >metabolising
>> > enzymes!).
>> >
>> >
>> > Enjoy your weekends.
>> >
>> >
>> >
>> > Reza
>> >
>> >
>> >
>> >
>> > Reza Morovat
>> > Clinical Biochemist
>> > John Radcliffe Hospital
>> > Oxford
>> >
>> >
>> >
>> > Date: Fri, 12 Jun 2009 08:51:51 +0000
>> >From: [log in to unmask]
>> > Subject: Re: Vitamin D over requesting
>> > To: [log in to unmask]
>> >
>> >
>> >
>> >
>> >
>> >
>> >
>> >
>> > Thank you Brian,
>> >
>> >
>> >
>> > Does this mean that vit D decreases in inflammation in
>>a
>> >way that is independent from any nutritional problem?
>> >
>> >
>> >
>> > What can the extent of such decreases be? 10% of basal
>> >vit D values? 20%? 30%? more?
>> >
>> >
>> >
>> > Best regards,
>> >
>> >
>> >
>> > Joseph
>> >
>> >
>> > Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
>> > Laboratoire de Biologie Polyvalente
>> > Centre Hospitalier Général
>> > 12027 Rodez Cedex 9
>> >France
>> >
>> >
>> >
>> >> Date: Thu, 11 Jun 2009 11:51:57 +0100
>> >> From: [log in to unmask]
>> >> Subject: Re: Vitamin D over requesting
>> >> To: [log in to unmask]
>> >>
>> >> The large literature describing the association of
>>low
>> >>vitamin D values with disease, morbidity and mortality
>> >> without classic symptoms of D deficiency seems to
>> >>universally ignore the evidence that vitamin D-binding
>> >> protein, otherwise known as Gc-globulin, is a
>>negative
>> >>acute phase protein like albumin.
>> >>
>> >> In addition to binding vitamin D Gc-globulin also
>>binds
>> >>actin, which is released from cells damaged by tissue
>> >> injury, inflammation or sepsis. The complex is then
>> >>cleared rapidly from the circulation, very low values
>> >> correlating with poor survival (reviewed by Meier et
>>al,
>> >>Clin Chem 2006;52:1247-1253). So low D values do not
>> >> necessarily indicate D-deficiency.
>> >>
>> >> Brian Payne
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